5,824 research outputs found
Fundamental Limits of "Ankylography" due to Dimensional Deficiency
Single-shot diffractive imaging of truly 3D structures suffers from a
dimensional deficiency and does not scale. The applicability of "ankylography"
is limited to objects that are small-sized in at least one dimension or that
are essentially 2D otherwise.Comment: 2 pages, no figur
Purification and Characterization of a New D-Galactose-Specific Lectin from the Housefly, Musca domestica, and Its Antiproliferative Effect on Human K562 and MCF-7 Tumor Cells
In the present work, a D-galactose-specific lectin with novel N-terminal sequence was purified from Musca domestica L. (Diptera: Muscidae) pupae. The purification was performed using affinity chromatography, ultra-filtration, and HPLC. The haemagglutinating activity of M. domestica lectin was specifically inhibited by D-galactose. The haemagglutinating activity of this lectin was stable at temperatures up to 65° C and in pH ranging from 4 to 8. Salts including FeCl3 and MnCl2 inhibited the haemagglutinating process, whereas NaCl, KCl, CaCl2, MgCl2, ZnCl2, and AlCl3 did not. By SDS-PAGE, purified M. domestica pupae lectin yielded a single band with a molecular weight of 40 kDa, with or without reduction of β-mercaptoethanol, and it could be stained with Alcian Blue 8 GX. The morphology of purified lectin was observed by atomic force microscopy, which indicated that M. domestica lectin was an 8.27 nm high, globular shaped glycoprotein with a 1.41 nm high polysaccharide chain. In addition, antiproliferative activity of this lectin against tumor cells K562 and MCF-7 was determined with a colorimetric assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, which showed that the antiproliferative process was time- and dose-dependent with an IC50 of 5.7 and 6.7 at 24 h, 5.5 and 6.4 at 36 h, 5.2 and 6.5 µM at 48 h, respectively
Electronic Properties of Boron and Nitrogen doped graphene: A first principles study
Effect of doping of graphene either by Boron (B), Nitrogen (N) or co-doped by
B and N is studied using density functional theory. Our extensive band
structure and density of states calculations indicate that upon doping by N
(electron doping), the Dirac point in the graphene band structure shifts below
the Fermi level and an energy gap appears at the high symmetric K-point. On the
other hand, by B (hole doping), the Dirac point shifts above the Fermi level
and a gap appears. Upon co-doping of graphene by B and N, the energy gap
between valence and conduction bands appears at Fermi level and the system
behaves as narrow gap semiconductor. Obtained results are found to be in well
agreement with available experimental findings.Comment: 11 pages, 4 figures, 1 table, submitted to J. Nanopart. Re
Experimental measurement-based quantum computing beyond the cluster-state model
The paradigm of measurement-based quantum computation opens new experimental
avenues to realize a quantum computer and deepens our understanding of quantum
physics. Measurement-based quantum computation starts from a highly entangled
universal resource state. For years, clusters states have been the only known
universal resources. Surprisingly, a novel framework namely quantum computation
in correlation space has opened new routes to implement measurement-based
quantum computation based on quantum states possessing entanglement properties
different from cluster states. Here we report an experimental demonstration of
every building block of such a model. With a four-qubit and a six-qubit state
as distinct from cluster states, we have realized a universal set of
single-qubit rotations, two-qubit entangling gates and further Deutsch's
algorithm. Besides being of fundamental interest, our experiment proves
in-principle the feasibility of universal measurement-based quantum computation
without using cluster states, which represents a new approach towards the
realization of a quantum computer.Comment: 26 pages, final version, comments welcom
Efficient and long-lived quantum memory with cold atoms inside a ring cavity
Quantum memories are regarded as one of the fundamental building blocks of
linear-optical quantum computation and long-distance quantum communication. A
long standing goal to realize scalable quantum information processing is to
build a long-lived and efficient quantum memory. There have been significant
efforts distributed towards this goal. However, either efficient but
short-lived or long-lived but inefficient quantum memories have been
demonstrated so far. Here we report a high-performance quantum memory in which
long lifetime and high retrieval efficiency meet for the first time. By placing
a ring cavity around an atomic ensemble, employing a pair of clock states,
creating a long-wavelength spin wave, and arranging the setup in the
gravitational direction, we realize a quantum memory with an intrinsic spin
wave to photon conversion efficiency of 73(2)% together with a storage lifetime
of 3.2(1) ms. This realization provides an essential tool towards scalable
linear-optical quantum information processing.Comment: 6 pages, 4 figure
Experimental Demonstration of Five-photon Entanglement and Open-destination Teleportation
Universal quantum error-correction requires the ability of manipulating
entanglement of five or more particles. Although entanglement of three or four
particles has been experimentally demonstrated and used to obtain the extreme
contradiction between quantum mechanics and local realism, the realization of
five-particle entanglement remains an experimental challenge. Meanwhile, a
crucial experimental challenge in multi-party quantum communication and
computation is the so-called open-destination teleportation. During
open-destination teleportation, an unknown quantum state of a single particle
is first teleported onto a N-particle coherent superposition to perform
distributed quantum information processing. At a later stage this teleported
state can be readout at any of the N particles for further applications by
performing a projection measurement on the remaining N-1 particles. Here, we
report a proof-of-principle demonstration of five-photon entanglement and
open-destination teleportation. In the experiment, we use two entangled photon
pairs to generate a four-photon entangled state, which is then combined with a
single photon state to achieve the experimental goals. The methods developed in
our experiment would have various applications e.g. in quantum secret sharing
and measurement-based quantum computation.Comment: 19 pages, 4 figures, submitted for publication on 15 October, 200
Additive and multiplicative hazards modeling for recurrent event data analysis
<p>Abstract</p> <p>Background</p> <p>Sequentially ordered multivariate failure time or recurrent event duration data are commonly observed in biomedical longitudinal studies. In general, standard hazard regression methods cannot be applied because of correlation between recurrent failure times within a subject and induced dependent censoring. Multiplicative and additive hazards models provide the two principal frameworks for studying the association between risk factors and recurrent event durations for the analysis of multivariate failure time data.</p> <p>Methods</p> <p>Using emergency department visits data, we illustrated and compared the additive and multiplicative hazards models for analysis of recurrent event durations under (i) a varying baseline with a common coefficient effect and (ii) a varying baseline with an order-specific coefficient effect.</p> <p>Results</p> <p>The analysis showed that both additive and multiplicative hazards models, with varying baseline and common coefficient effects, gave similar results with regard to covariates selected to remain in the model of our real dataset. The confidence intervals of the multiplicative hazards model were wider than the additive hazards model for each of the recurrent events. In addition, in both models, the confidence interval gets wider as the revisit order increased because the risk set decreased as the order of visit increased.</p> <p>Conclusions</p> <p>Due to the frequency of multiple failure times or recurrent event duration data in clinical and epidemiologic studies, the multiplicative and additive hazards models are widely applicable and present different information. Hence, it seems desirable to use them, not as alternatives to each other, but together as complementary methods, to provide a more comprehensive understanding of data.</p
Tripartite interactions between two phase qubits and a resonant cavity
The creation and manipulation of multipartite entangled states is important
for advancements in quantum computation and communication, and for testing our
fundamental understanding of quantum mechanics and precision measurements.
Multipartite entanglement has been achieved by use of various forms of quantum
bits (qubits), such as trapped ions, photons, and atoms passing through
microwave cavities. Quantum systems based on superconducting circuits have been
used to control pair-wise interactions of qubits, either directly, through a
quantum bus, or via controllable coupling. Here, we describe the first
demonstration of coherent interactions of three directly coupled
superconducting quantum systems, two phase qubits and a resonant cavity. We
introduce a simple Bloch-sphere-like representation to help one visualize the
unitary evolution of this tripartite system as it shares a single microwave
photon. With careful control and timing of the initial conditions, this leads
to a protocol for creating a rich variety of entangled states. Experimentally,
we provide evidence for the deterministic evolution from a simple product
state, through a tripartite W-state, into a bipartite Bell-state. These
experiments are another step towards deterministically generating multipartite
entanglement in superconducting systems with more than two qubits
Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells
The pregnane X receptor (PXR) was previously known as a xenobiotic receptor. Several recent studies suggested that PXR also played an important role in lipid homeostasis but the underlying mechanism remains to be clearly defined. In this study, we found that rifampicin, an agonist of human PXR, induced lipid accumulation in HepG2 cells. Lipid analysis showed the total cholesterol level increased. However, the free cholesterol and triglyceride levels were not changed. Treatment of HepG2 cells with rifampicin induced the expression of the free fatty acid transporter CD36 and ABCG1, as well as several lipogenic enzymes, including stearoyl-CoA desaturase-1 (SCD1), long chain free fatty acid elongase (FAE), and lecithin-cholesterol acyltransferase (LCAT), while the expression of acyl:cholesterol acetyltransferase(ACAT1) was not affected. Moreover, in PXR over-expressing HepG2 cells (HepG2-PXR), the SCD1 expression was significantly higher than in HepG2-Vector cells, even in the absence of rifampicin. Down-regulation of PXR by shRNA abolished the rifampicin-induced SCD1 gene expression in HepG2 cells. Promoter analysis showed that the human SCD1 gene promoter is activated by PXR and a novel DR-7 type PXR response element (PXRE) response element was located at -338 bp of the SCD1 gene promoter. Taken together, these results indicated that PXR activation promoted lipid synthesis in HepG2 cells and SCD1 is a novel PXR target gene. © 2013 Zhang et al
On-demand semiconductor single-photon source with near-unity indistinguishability
Single photon sources based on semiconductor quantum dots offer distinct
advantages for quantum information, including a scalable solid-state platform,
ultrabrightness, and interconnectivity with matter qubits. A key prerequisite
for their use in optical quantum computing and solid-state networks is a high
level of efficiency and indistinguishability. Pulsed resonance fluorescence
(RF) has been anticipated as the optimum condition for the deterministic
generation of high-quality photons with vanishing effects of dephasing. Here,
we generate pulsed RF single photons on demand from a single,
microcavity-embedded quantum dot under s-shell excitation with 3-ps laser
pulses. The pi-pulse excited RF photons have less than 0.3% background
contributions and a vanishing two-photon emission probability.
Non-postselective Hong-Ou-Mandel interference between two successively emitted
photons is observed with a visibility of 0.97(2), comparable to trapped atoms
and ions. Two single photons are further used to implement a high-fidelity
quantum controlled-NOT gate.Comment: 11 pages, 11 figure
- …